Chia-Po Fu
Chung Shan Medical University, Taiwan.
Title: The effect of weight loss on epicardial adipose tissue thickness and its associative changes of cytokines in men with metabolic syndrome: a prospective weight reduction study.
Biography
Biography: Chia-Po Fu
Abstract
Obesity is a recognized risk factor for cardiovascular disease, diabetes, and hypertension.Adipose tissue secretes numerous proinflammatory cytokines, chemokines, and adipokines. Furthermore, obesity was also correlated with depression and the possible mechanism remains unclear. Epicardial adipose tissue (EAT) induces activated inflammatory cells secreting cytokines, including soluble CD40 ligand (sCD40L). In turn the serumsCD40L can trigger inflammatory responses. We initiated a prospective weight reduction study in men with metabolic syndrome and try to elucidated the effect of weight loss on epicardial fat thickness and insulin resistance, mechanism exploration of depression and (Brain-derived neurotrophic factor) BDNF, and its associative changes of cytokines, like paraoxonase-1, monocyte chemoattractant protein-1 (MCP-1), serum cystatin C, urinary N-acetyl glucosaminidase (NAG) and its indicative clinical significances. We also elucidated that different area of EAT thickness, examined by MRI, has different clinical significance and relationships with cytokines.